The Renton Fire Department (RFD) said the fire started in the 300 block of S. 2nd around 3:30 a.m.
Crews had to immediately call for a full alarm when they arrived with smoke and fire bursting out of the home.
Skyway Fire, King County medics and the Tukwila Fire Department all ended up coming to help.
RFD officials have not yet determined how the fire started, the person who went to the hospital suffered smoke inhalation.
Firefighters say the building sprinkler system actually helped contain the fire itself to one room.