The call came in around 5:45 a.m on Thursday for a fire at the Adams High-Rise Apartments on Adams Avenue.
Officials say the fire started in a storage unit on the second floor. The sprinkler system did go off.
Two residents were taken to the hospital for breathing in smoke, and a firefighter does have a minor injury.
A fire inspector is looking into the cause.
This is also the second fire at a high-rise in Scranton in less than 24 hours.