The fire appeared to be largely in or near a utility or service area (trash receptacle, ice machine, etc.) at the iconic structure, authorities said.
A third person treated at the scene declined further care, said Brian Humphrey of the Los Angeles Fire Department.
Firefighters were dispatched at 6:49 a.m. to the greater alarm blaze at 404 S. Figueroa St., Humphrey said.
The fire, which was held in check by the structure’s sprinkler system, was under control at 7:20 a.m., he added.
“Staff and patrons who calmly and safely evacuated the iconic building are now being provided hotel access, with patrol below the 22nd floor being allowed to return to guest accommodations,” Humphrey said. “Many of the 113 firefighters assigned to this incident are now working closely with hotel staff to manage residual smoke on floors 22-66 and localized water removal on floors 21 and 22.”