Firefighters received a report at 1:11 a.m. that a truck had slammed into and gone inside a two-story building in the 5700 block of Moon Drive, just north of Highway 101 and about a block west of South Victoria Avenue. The vehicle and the building both apparently caught fire.
Crews at the scene discovered one victim and requested an ambulance.
One man was taken to a local trauma center at 1:35 a.m. for injuries, just as the vehicle fire was reported knocked down. The structure fire was being held in check by a sprinkler system, firefighters said.
Officials said the fire was controlled within 23 minutes of firefighters arrival and put out an hour later.
Two other victims apparently left the scene, authorities reported to dispatchers.
In addition to Ventura City Fire, firefighters from Ventura County, Oxnard and Santa Paula fire departments as well as Ventura police also responded.